Is fibroblast Interferon antigenic for man?
نویسندگان
چکیده
منابع مشابه
Antigenic Variation in a Rabbit Fibroblast Strain1
ULTURED mammalian fibroblasts are potentially useful for studying questions of genetic variation in the somatic cells of higher organisms. Fibroblasts are of particular interest because generally they are the only cells which grow in cultures initiated from nonmalignant tissue. In addition, retention of the diploid state in vitro is associated with the fibroblast morphology in several species, ...
متن کاملGamma interferon is the lymphokine and beta interferon the monokine responsible for inhibition of fibroblast collagen production and late but not early fibroblast proliferation
Human peripheral blood mononuclear cells activated with concanavalin A (Con A) or lipopolysaccharide (LPS) produce, respectively, lymphokines (LK) of 50,000 Mr or monokines (MK) of 20,000 Mr that inhibit the growth and collagen production of cultured human dermal fibroblasts. Because antigenic typing of the antiviral activity of these LK and MK preparations revealed that LK contained mainly gam...
متن کاملPharmacokinetic properties of human fibroblast and leukocyte interferon in rabbits.
When rabbits were given intramuscular injections of the same quantities of human leukocyte or fibroblast interferons, the former produced moderately higher levels of circulating interferon. Fibroblast interferon was not cleared faster from circulation, nor was direct inactivation by rabbit blood responsible for this difference.
متن کاملThe absence of introns within a human fibroblast interferon gene.
Experiments in which immobilised restriction fragments of genomic DNA were hybridised with a cloned human fibroblast interferon cDNA indicate that the homologous chromosomal genes exist in only one basic arrangement. This is in marked contrast to recent studies by Nagata et al. (1) showing that there are at least eight gene arrangements for human leukocyte interferon. Having isolated a chromoso...
متن کاملDifferential susceptibility of chlamydiae to exogenous fibroblast interferon.
Mouse fibroblasts (L cells) were incubated for 5 h with 1,000 U of murine fibroblast interferon (MuIFN alpha+ beta) per ml and then were infected with either Chlamydia trachomatis (LGV 440), C. psittaci (6BC), or C. psittaci (Cal 10). Intracellular development of C. trachomatis was reduced 90% in interferon-treated cells 24 h after infection when compared with controls, whereas C. psittaci grow...
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ژورنال
عنوان ژورنال: Nature
سال: 1981
ISSN: 0028-0836,1476-4687
DOI: 10.1038/289446a0